Complete and comprehensive reference on the principles of diagnostic and therapeutic techniques using pressure oscillation

Pressure Oscillation in Biomedical Diagnostics and Therapy presents key findings in imaging, diagnostics, and therapies using high and low frequency pressure waves in a concise and easy-to-understand way, focusing primarily on the cardiovascular and pulmonary systems that utilize acoustics (mechanical wave motion). The work provides basic background in relevant acoustic theory as well as specific technical information associated with modern medical applications. Low frequency acoustics (pressure oscillation) and some aspects of ultrasound (radiation force) are also reviewed. The principles in the work can be extended to include other areas relating to materials and metal diagnostics.

To allow for maximum reader comprehension regardless of current expertise on the subject, each chapter includes a brief history, current developments, and practical applications of the topic covered within. Furthermore, all chapters are based on engineering and physiological principles to deliver practical technologies. Sample topics covered in the work include:

Pressure Oscillation in Biomedical Diagnostics and Therapy links pressure oscillation (PO) and biomedical diagnostics and therapy for scholars and practitioners. It is an essential resource for all professionals who wish to be on the cutting edge of treating lung diseases such as obstructive sleep apnea, asthma, and respiratory distress syndrome.

Ahmed Al-Jumaily is Professor of Biomechanical Engineering and Director, Institute of Biomedical Technologies, Auckland University of Technology, New Zealand. He is a Fellow member of the American Society of Mechanical Engineering (ASME). His current research focuses on biomedical applications with particular interest in the application of vibration and acoustics to airways constriction therapies and artery non-invasive diagnostics.

Lulu Wang is currently a Distinguished Professor at Shenzhen Technology University, China. She is a Fellow of American Society of Mechanical Engineers. Her research interests include medical devices, electromagnetic sensing and imaging, and computational mechanics. She has been selected as the World's Top 2% Scientists 2021 (by Stanford University). She is an active topic/track organizer of several international conferences.

CHAPTER I PRESSURE WAVES FOR DIAGNOSTICS AND THERAPY

1.1 INTRODUCTION

1.2 SIGNIFICANCE OF BIOLOGICAL SYSTEM MODELLING

1.3 WAVE EQUATION

1.4 GOVERNING EQUATION

1.4.1 Assumptions

1.4.2 Derivation

1.4.3 Solution

1.5 BIFURCATION

1.6 DIAGNOSTICS AND THERAPY

1.6.1 Diagnostics Applications

1.6.2 Therapy Applications

1.7 CLOSURE

1.8 REFRENCES

PART I: DIAGNOSTICS AND IMIGING

CHAPTER II: PULSE WAVE FOR ARTERIAL DIAGNOSTICS

2.1 INTRODUCTION

2.2 CARDIOVASCULAR SYSTEM

2.2.1 Arterial System

2.2.2 Properties of Arteries

2.2.3 Arterial Stiffness (AS)

2.3 NON-INVASIVE ARTERIAL STIFFNESS DETECTION

2.3.1 Local Methods

2.3.2 Regional Methods

2.3.3 Waveform Analysis Methods

2.4 ARTERIAL MODEL DEVELOPMENT

2.5 LUMPED MODELLING OF THE AORTA AND BRACHIAL ARTERIES...

2.5.1 Input Signal

2.5.2 Wave Reflection Locations

2.5.3 Cuff-Soft Tissue -Brachial Artery Model

2.5.4 Brachial Artery Model

2.5.5 Combined Model

2.6 ARTERIAL BLOOD PRESSURE

2.6.1 Pulse Pressure

2.6.2 Mean Arterial Pressure

2.6.3 Non-invasive Blood Pressure Measurement Methods

2.6.4 Proposed Blood Pressure Measurement Method

2.7 ARTIFICIAL NEURAL NETWORK CLASSIFICATION

2.8 PULSE WAVE

2.8.1 Pulse Wave History

2.8.2 Pulse Wave Types

2.8.3 Augmentation Index

2.8.4 Pulse Wave Velocity (PWV

2.8.5 Arterial Stiffness Index

2.8.6 Cardiac Output (CO

2.8.7 Pulse Wave Analysis (PWA) Methods

2.9 MEDICAL APPLICATIONS OF PULSE WAVE ANALYSIS

2.9.1 Pulse Wave Analysis for the Early Detection of Cardiovascular Disease

2.9.2 Pulse Wave Analysis in Chronic Obstructive Pulmonary Disease

2.9.3 Pulse Wave in Traditional Chinese Medicine (TCM)

2.9.4 Pulse Wave Analysis for the Prediction of Preeclampsia

BIBLIOGRAPHY

CHAPTER III: RADIATION FORCE

3.1 INTRODUCTION

3.2 ACOUSTIC RADIATION FORCE

3.2.1 Types of Radiation Force

3.2.2 Acoustic Radiation Force History

3.2.3 Applications of Acoustic Radiation Force

3.2.4 Acoustic Radiation Force Based Elasticity Imaging Techniques

3.2.5 Commercial Implementations of Acoustic Radiation Force Based Imaging

3.3 VIBRO ACOUSTOGRAPHY

3.3.1 Soft Tissue Material Properties

3.3.2 Dynamic Radiation Force in Vibro-Acoustography

3.3.3 Acoustic Emission

3.3.4 Ultrasound Beam Forming

3.3.5 Image Formation

3.3.6 Experimental System

3.3.7 Multi-frequency Vibro-Acoustography

3.4 VIBRO-ACOUSTOGRAPHY APPLICATIONS

3.4.1 Breast Imaging Application

3.4.2 Arteries Imaging Application

3.4.3 Prostate Imaging Application

3.4.4 Other Applications

3.5 GENERAL REMARKS ON VA

3.5.1 Benefits and Limitations of VA

3.5.2 Limitations of VA

3.5.3 Comparison of Vibro-Acoustography with Pulseecho Systems

3.5.4 Future Directions

BIBLIOGRAPHY

CHAPTER IV:  HUMAN RESPIRATORY SYSTEM

4.1 INTRODUCTION

4.2 RESPIRATORY SYSTEM

4.2.1 Upper Airways

4.2.2 Lower Airways

4.3 LUNG DEVELOPMENT

4.4 GAS EXCHANGE AND CONTROL

4.5 RESPIRATORY SYSTEM MECHANICS

4.5.1 Mechanical Properties

4.5.2 Airway Resistance

4.5.3 Surface Tension

4.5.4 Elastance and Compliance

4.5.5 Impedance

4.6 RESPIRATORY SYSTEM MODELS

4.7 MEASUREMENT METHODS

4.7.1 Lung Function Tests

4.7.2 Spirometry

4.7.2 Forced Oscillation Technique

4.8 RESPIRATORY SYSTEM DISEASES

4.8.1 Obstructive Lung Diseases

4.8.2 Restrictive Lung Diseases

4.9 DIAGNOSIS OF LUNG DISEASES

4.10 RESPIRATORY DISEASES TREATMENT

4.10.1 Surfactant Therapy

4.10.2 Ventilation Treatments

4.10.3 Ventilation Techniques using Pressure Oscillations

4.10.4 High Frequency Ventilation

4.10.5 Continuous Positive Airway Pressure (CPAP) with Pressure Oscillations

4.10.6 Noisy ventilation

4.10.7 The Role of Vibration

4.11 CLOSURE

BIBLIOGRAPHY

CHAPTER V: FORCED OSCILLATION TECHNIQUE

5.1 INTRODUCTION

5.2 FORCED OSCILLATION TECHNIQUE

5.2.1 FOT Development History

5.2.2 Forced Oscillation Technique Types

5.2.3 FOT Setup

5.3 MEASUREMENT ARRANGEMENT

5.3.1 Resistance Measurement

5.3.2 Impedance Measurement Method

5.4 CLINICAL APPLICATIONS

5.4.1 FOT in Responsiveness Tests

5.4.2 FOT for Detecting Asthma Phenotypes

5.4.3 FOT in Patients Subjected to Ventilator Support

5.4.4 Monitoring of Respiratory Mechanics

5.5 CONCLUDING REMARKS

BIBLIOGRAPHY

PART TWO: LUNG THERAPIES

CHAPTER VI: OBSTRUCTIVE SLEEP APNEA

6.1 INTRODUCTION

6.2 OBSTRUCTIVE SLEEP APNEA

6.2.1 Anatomic Contributors to OSA

6.2.2 OSA Risks and Symptoms

6.2.3 OSA Diagnostic Methods

6.3 TREATMENT OPTION FOR OSA

6.4 SURGICAL TREATMENTS

6.4.1 Palatal Surgeries

6.4.2 Hypopharyngeal Procedures

6.4. 3 Other Procedures

6.5 CONTINUOUS POSITIVE AIRWAY PRESSURE

6.5.1 CPAP Principle

6.5.2 CPAP Main Components

6.5.3 Titration Pressure

6.6 OTHER FORMS OF CPAP

6.6.1 Bi-Level Positive Airway Pressure

6.6.2 Automatic Continuous Positive Airway Pressure

6.6.3 Auto Bi-Level Machines

6.6.4 Adaptive Pressure Support Servo-Ventilators

6.7 CLINICAL STUDIES

6.7.1 CPAP

6.7.2 Auto-CPAP

6.7.3 Clinical Comparison Studies of Auto CPAP and CPAP

6.8 SIDE EFFECTS WITH CPAP APPLICATIONS

6.9 SIGNIFICANCE OF PRESSURE OSCILLATION

6.9.1 Rationales

6.9.2 Pressure Oscillation

6.9.3 Pressure Oscillations Superimposed on CPAP

6.10 IMPROVEMENTS ON CPAP THERAPY

6.10.1 SIPO Modulate the Obstructed UA

6.10.2 SIPO for Saliva Stimulation

6.11 DEMONSTRATING SIPO CLINICALLY

6.11.1 Polysomnography setup

6.11.2 Saliva collection test

6.11.3 Concluding Remarks

BIBLIOGRAPHY

CHAPTER VII: PRESSURE OSCILLATIONS IN ASTHMA TREATMENT

7.1 INTRODUCTION

7.2 ASTHMA

7.2.1 Types of Asthma

7.2.2 Asthma Diagnostics

7.2.3 Asthma Treatment

7.2.3.1 Pharmacotherapy Treatments

7.2.3.2 Non-pharmacological Treatments

7.3 AIRWAY SMOOTH MUSCLES (ASM)

7.3.1 Structure of Airway Smooth Muscle

7.3.2 ASM Function in Health and Disease

7.3.3 ASM and Airway Responsiveness

7.3.4 Mechanical Properties of Airway Smooth Muscle

7.4 BREATHING DYNAMICS AND ASM

7.4.1 ASM Dynamics

7.4.2 Modelling of Airway Smooth Muscle Dynamics

7.5 LENGTH OSCILLATION BRONCHODILATION

7.5.1 Filament Sliding Model

7.5.2 Finite Duration for Length Steps

7.5.3 ASM Response

7.6 LENGTH OSCILLATION BRONCHOPROTECTION

7.6.1 Effect of Length Oscillations on ASM Reactivity and Cross-Bridge Cycling

7.6.2 Concluding Remarks

7.7 ENGINEERING PERSPECTIVES OF CONTRACTION-RELAXATION MECHANISM

7. 8. ANIMAL MODELS

7.8.1 Mouse Anatomy

7.8.2 Acute and Chronical Asthmatic Models

7.8.3 Model Limitations

7.9 MODEL SENSITIZATION

7.9.1 Sensitization Assessment

7.9.2 AHR / Plethysmography

7.9.3 ELISA (IgE)

7.9.4 BAL

7.10 SUPERIMPOSED PRESSURE OSCILLATION

7.10.1 Experimental layout

7.10.2 Nebulization System for the Drugs and Allergen

7.10.3 Pressure Oscillation Setup

7.11 IN VIVO TEST

7.11.1 Relaxation

7.11.2 Lung Resistance

7.11.3 Compliance

7.11.4 Concluding Remarks

BIBLIOGRAPHY

CHAPTER VIII: PRESSURE OSCILLATION IN NEONATAL RESPIRATORY DISEASES TREATMENT

8.1 INTRODUCTION

8.2 NEONATAL RESPIRATORY DISEASES

8.2.1 Bronchopulmonary Dysplasia

8.2.2 Pneumonia

8.2.3 Persistent Pulmonary Hypertension of the Newborn

8.2.4 Meconium Aspiration Syndrome

8.2.5 Respiratory Distress Syndrome

8.2.6 Neonatal RDS Treatments

8.2.7 Role of Pressure Oscillations

8.3 HIGH-FREQUENCY VENTILATION

8.3.1 Mechanics of High-Frequency Oscillation

8.3.2 Modalities of High-Frequency Ventilation

8.3.3 High-Frequency Oscillatory Ventilation System

8.3.4 Gas Transport During HFOV

8.3.5 Control of Gas Exchange

8.3.6 Ventilator

8.3.7 Adjusting Ventilatory Parameters

8.3.8 Noninvasive Assessment of Lung Volume

8.3.9 Weaning

8.4 NOISY VENTILATION

8.5 CONTINUOUS POSITIVE AIRWAY PRESSURE

8.5.1 Nasal CPAP

8.5.2 Bubble CPAP System

8.6 MODELLING OF BUBBLE CPAP

8.6.1 Model Formulation

8.6.2 Structural Correlation

8.6.3 Results and Discussion

8.7 CLINICAL APPLICATIONS OF PRESSURE OSCILLATIONS

8.7.1 HFOV in the Neonate and Infant

8.7.2 HFOV in the Children

8.7.3 HFOV in Adolescent and Adult

8.7.4 Clinical Benefits and Disadvantages of HFOV

8.7.5 Clinical Applications of CPAP

BIBLIOGRAPHY