Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders. These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence their effective management. This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classical and contemporary techniques to enable practitioners in neurology and neuropathology to better understanding of the disease processes underlying patients' presentations and to formulate appropriate management plans. Peripheral Nerve Disorders: Pathology and Genetics is a valuable resource for neurologists, neuropathologists, pathologists, neurobiologists and geneticists.

InhaltsangabeContributor list vii Foreword x Preface xi Abbreviations xiii 1 Clinical assessment and classification of peripheral nerve diseases 1 Pierre Bouche 2 Combined muscle and nerve biopsy 12 Anne Vital 3 Cutaneous nerve biopsy 15 Claudia Sommer and Maria Nolano 4 Methods for examination of peripheral nerve 24 Juan M. Bilbao Douglas C. Anthony and Umberto De Girolami 5 Complications from nerve biopsy 30 Richard A.C. Hughes 6 Anatomy of the peripheral nerve 32 Rosalind King 7 Basic pathology of the peripheral nervous system 38 J. Michael Schröder and Joachim Weis 8 Introduction to the hereditary neuropathies 59 Joachim Weis and Jan Senderek 9 Autosomal dominant demyelinating Charcot-Marie-Tooth (CMT1) neuropathies 62 JeanMichel Vallat and Stéphane Mathis 10 Autosomal dominant neuropathy of the axonal Charcot-Marie-Tooth type 2 72 J. Michael Schröder Joachim Weis and Jan Senderek 11 Autosomal recessive demyelinating or axonal Charcot-Marie-Tooth neuropathy 85 Kristl G. Claeys Martin Lammens Jan Senderek and Joachim Weis 12 Dominant and recessive intermediate CMT (CMTDI and CMTRI) 102 Joachim Weis Andreas Roos Istvan Katona Kristl G. Claeys and Jan Senderek 13 Xlinked neuropathy of the CharcotMarieTooth type 111 J. Michael Schröder and Jan Senderek 14 Hereditary sensory and autonomic neuropathy 119 Rosalind King 15 Hereditary neuropathy with liability to pressure palsy 126 Benjamin Ellezam 16 Familial amyloid polyneuropathy 131 Manuel Melo Pires Ricardo Taipa and António Guimarães 17 Peripheral neuropathies in mitochondrial disorders 138 Benoît Funalot 18 Giant axonal neuropathy 142 Robert Ouvrier and Manoj Menezes 19 Neuroaxonal dystrophy 146 Robert Ouvrier and Manoj Menezes 20 Peripheral nerve involvement in neurolipidoses 149 Robert Ouvrier and Manoj Menezes 21 Other hereditary neuropathies 158 Stéphane Mathis Meriem Tazir and Jean-Michel Vallat 22 Adult polyglucosan body disease 167 Alexander Lossos Or Kakhlon and Dov Soffer 23 Polyneuropathies associated with neurofibromatosis 172 Joachim Weis 24 Vasculitides 175 Michael P. Collins and P. James B. Dyck 25 Infectious and tropical neuropathies 196 Leila Chimelli and Jean-Michel Vallat 26 Sarcoid neuropathy 210 Anne Vital 27 GuillainBarré syndromes and chronic inflammatory demyelinating polyradiculoneuropathy 214 Laurent Magy 28 Diabetic neuropathies 224 Robert E. Schmidt 29 Neuropathies in metabolic diseases other than diabetes mellitus 233 Martin Lammens 30 Toxic neuropathies 238 Sebastian Brandner 31 Polyneuropathy associated with a monoclonal gammopathy 247 Yuichi Kawagashira Haruki Koike Jean-Michel Vallat and Gen Sobue 32 Paraneoplastic peripheral neuropathies 259 JeanChristophe Antoine 33 Neuropathies in malnutrition and alcoholism 267 Martin Lammens 34 Critical illness polyneuropathy 273 Douglas C. Anthony and David Lacomis 35 Nonvasculitic ischemic neuropathies 276 Robert E. Schmidt 36 Traumatic and compressive lesions of peripheral nerves 280 Carlos OrtizHidalgo and Roy O. Weller 37 Localized hypertrophic neuropathy intraneural perineurioma polyneuropathy with perineurial cell hyperplasia and minifascicular neuropathy 287 Joachim Weis 38 Neurolymphomatosis and rare focal or multifocal lesions 291 Joachim Weis Index 294

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